منابع مشابه
Mitochondrial Steve: paternal inheritance of mitochondria in humans
Mitochondrial DNA is the primary tool in the investigation of recent evolutionary history, particularly for uncovering human origins and expansion. Maternal inheritance of mitochondria enables models of population history to be much simpler that those needed for the analysis of nuclear DNA. The recent report of a man with his father’s mitochondria suggests a rethink of mitochondrial evolutionar...
متن کاملMitochondrial endonuclease G mediates breakdown of paternal mitochondria upon fertilization.
Mitochondria are inherited maternally in most animals, but the mechanisms of selective paternal mitochondrial elimination (PME) are unknown. While examining fertilization in Caenorhabditis elegans, we observed that paternal mitochondria rapidly lose their inner membrane integrity. CPS-6, a mitochondrial endonuclease G, serves as a paternal mitochondrial factor that is critical for PME. We found...
متن کاملAccentuating The Positive Or Eliminating The Negative? Paternal Incarceration And Caregiver-Child Relationship Quality
Mounting evidence links paternal incarceration to harmful outcomes for the children of incarcerated fathers. These findings hold across a host of important behavioral, developmental, and attainment outcomes, including mental health and behavioral problems, substance use, educational attainment, and social inequality. The process by which paternal incarceration causes poor outcomes is much less ...
متن کاملElimination of paternal mitochondria in mouse embryos occurs through autophagic degradation dependent on PARKIN and MUL1
A defining feature of mitochondria is their maternal mode of inheritance. However, little is understood about the cellular mechanism through which paternal mitochondria, delivered from sperm, are eliminated from early mammalian embryos. Autophagy has been implicated in nematodes, but whether this mechanism is conserved in mammals has been disputed. Here, we show that cultured mouse fibroblasts ...
متن کاملMieap, a p53-Inducible Protein, Controls Mitochondrial Quality by Repairing or Eliminating Unhealthy Mitochondria
Maintenance of healthy mitochondria prevents aging, cancer, and a variety of degenerative diseases that are due to the result of defective mitochondrial quality control (MQC). Recently, we discovered a novel mechanism for MQC, in which Mieap induces intramitochondrial lysosome-like organella that plays a critical role in the elimination of oxidized mitochondrial proteins (designated MALM for Mi...
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ژورنال
عنوان ژورنال: Nature Reviews Molecular Cell Biology
سال: 2016
ISSN: 1471-0072,1471-0080
DOI: 10.1038/nrm.2016.99